diff --git a/apm-sniffer/apm-sdk-plugin/jdbc-commons/src/main/java/org/skywalking/apm/plugin/jdbc/ConnectionServiceMethodInterceptor.java b/apm-sniffer/apm-sdk-plugin/jdbc-commons/src/main/java/org/skywalking/apm/plugin/jdbc/ConnectionServiceMethodInterceptor.java
index b3476192a..712934b39 100644
--- a/apm-sniffer/apm-sdk-plugin/jdbc-commons/src/main/java/org/skywalking/apm/plugin/jdbc/ConnectionServiceMethodInterceptor.java
+++ b/apm-sniffer/apm-sdk-plugin/jdbc-commons/src/main/java/org/skywalking/apm/plugin/jdbc/ConnectionServiceMethodInterceptor.java
@@ -29,8 +29,11 @@ import org.skywalking.apm.agent.core.plugin.interceptor.enhance.MethodInterceptR
 import org.skywalking.apm.plugin.jdbc.trace.ConnectionInfo;
 
 /**
- * {@link ConnectionServiceMethodInterceptor} create an exit span when the client call the following methods in the
- * class that extend {@link java.sql.Connection}. 1. close 2. rollback 3. releaseSavepoint 4. commit
+ * {@link ConnectionServiceMethodInterceptor} create an exit span when the following methods execute:
+ * 1. close
+ * 2. rollback
+ * 3. releaseSavepoint
+ * 4. commit
  *
  * @author zhangxin
  */
diff --git a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/JDBC42PreparedStatementInstrumentation.java b/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/JDBC42PreparedStatementInstrumentation.java
deleted file mode 100644
index 04f877fba..000000000
--- a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/JDBC42PreparedStatementInstrumentation.java
+++ /dev/null
@@ -1,36 +0,0 @@
-/*
- * Copyright 2017, OpenSkywalking Organization All rights reserved.
- *
- * Licensed under the Apache License, Version 2.0 (the "License");
- * you may not use this file except in compliance with the License.
- * You may obtain a copy of the License at
- *
- *     http://www.apache.org/licenses/LICENSE-2.0
- *
- * Unless required by applicable law or agreed to in writing, software
- * distributed under the License is distributed on an "AS IS" BASIS,
- * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
- * See the License for the specific language governing permissions and
- * limitations under the License.
- *
- * Project repository: https://github.com/OpenSkywalking/skywalking
- */
-
-package org.skywalking.apm.plugin.jdbc.mysql.define;
-
-import org.skywalking.apm.agent.core.plugin.match.ClassMatch;
-
-import static org.skywalking.apm.agent.core.plugin.match.NameMatch.byName;
-
-/**
- * {@link JDBC42PreparedStatementInstrumentation} intercepts {@link com.mysql.jdbc.JDBC42PreparedStatement} class.
- *
- * @author zhangxin
- */
-public class JDBC42PreparedStatementInstrumentation extends AbstractPreparedStatementInstrumentation {
-    private static final String ENHANCE_CLASS = "com.mysql.jdbc.JDBC42PreparedStatement";
-
-    @Override protected ClassMatch enhanceClass() {
-        return byName(ENHANCE_CLASS);
-    }
-}
diff --git a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/PreparedStatementInstrumentation.java b/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/PreparedStatementInstrumentation.java
deleted file mode 100644
index bf0480f2d..000000000
--- a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/PreparedStatementInstrumentation.java
+++ /dev/null
@@ -1,38 +0,0 @@
-/*
- * Copyright 2017, OpenSkywalking Organization All rights reserved.
- *
- * Licensed under the Apache License, Version 2.0 (the "License");
- * you may not use this file except in compliance with the License.
- * You may obtain a copy of the License at
- *
- *     http://www.apache.org/licenses/LICENSE-2.0
- *
- * Unless required by applicable law or agreed to in writing, software
- * distributed under the License is distributed on an "AS IS" BASIS,
- * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
- * See the License for the specific language governing permissions and
- * limitations under the License.
- *
- * Project repository: https://github.com/OpenSkywalking/skywalking
- */
-
-package org.skywalking.apm.plugin.jdbc.mysql.define;
-
-import org.skywalking.apm.agent.core.plugin.match.ClassMatch;
-
-import static org.skywalking.apm.plugin.jdbc.mysql.define.MultiClassNameMatch.byMultiClassMath;
-
-/**
- * {@link JDBC42PreparedStatementInstrumentation} intercepts {@link com.mysql.jdbc.PreparedStatement} class.
- *
- * @author zhangxin
- */
-public class PreparedStatementInstrumentation extends AbstractPreparedStatementInstrumentation {
-
-    private static final String ENHANCE_CLASS = "com.mysql.jdbc.PreparedStatement";
-
-    @Override protected ClassMatch enhanceClass() {
-        return byMultiClassMath(ENHANCE_CLASS, "com.mysql.cj.jdbc.PreparedStatement");
-    }
-
-}
diff --git a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/resources/skywalking-plugin.def b/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/resources/skywalking-plugin.def
deleted file mode 100644
index 622dc29d0..000000000
--- a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/resources/skywalking-plugin.def
+++ /dev/null
@@ -1,6 +0,0 @@
-mysql=org.skywalking.apm.plugin.jdbc.mysql.define.DriverInstrumentation
-mysql=org.skywalking.apm.plugin.jdbc.mysql.define.ConnectionInstrumentation
-mysql=org.skywalking.apm.plugin.jdbc.mysql.define.CallableInstrumentation
-mysql=org.skywalking.apm.plugin.jdbc.mysql.define.PreparedStatementInstrumentation
-mysql=org.skywalking.apm.plugin.jdbc.mysql.define.JDBC42PreparedStatementInstrumentation
-mysql=org.skywalking.apm.plugin.jdbc.mysql.define.StatementInstrumentation
diff --git a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/pom.xml b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/pom.xml
similarity index 95%
rename from apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/pom.xml
rename to apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/pom.xml
index efcbfa22f..eb232bb10 100755
--- a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/pom.xml
+++ b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/pom.xml
@@ -25,10 +25,10 @@
     </parent>
     <modelVersion>4.0.0</modelVersion>
 
-    <artifactId>apm-mysql-2.x-plugin</artifactId>
+    <artifactId>apm-mysql-5.x-plugin</artifactId>
     <packaging>jar</packaging>
 
-    <name>mysql-2.x-plugin</name>
+    <name>mysql-5.x-plugin</name>
     <url>http://maven.apache.org</url>
 
     <properties>
@@ -45,7 +45,7 @@
         <dependency>
             <groupId>mysql</groupId>
             <artifactId>mysql-connector-java</artifactId>
-            <version>[2.0.14,6.0.6]</version>
+            <version>[5.1.22,6.0.6]</version>
             <scope>provided</scope>
         </dependency>
         <dependency>
diff --git a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/CreateCallableStatementInterceptor.java b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/CreateCallableStatementInterceptor.java
similarity index 100%
rename from apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/CreateCallableStatementInterceptor.java
rename to apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/CreateCallableStatementInterceptor.java
diff --git a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/CreatePreparedStatementInterceptor.java b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/CreatePreparedStatementInterceptor.java
similarity index 100%
rename from apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/CreatePreparedStatementInterceptor.java
rename to apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/CreatePreparedStatementInterceptor.java
diff --git a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/CreateStatementInterceptor.java b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/CreateStatementInterceptor.java
similarity index 100%
rename from apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/CreateStatementInterceptor.java
rename to apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/CreateStatementInterceptor.java
diff --git a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/StatementExecuteMethodsInterceptor.java b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/StatementExecuteMethodsInterceptor.java
similarity index 88%
rename from apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/StatementExecuteMethodsInterceptor.java
rename to apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/StatementExecuteMethodsInterceptor.java
index d8fbd58cd..779ae38b0 100644
--- a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/StatementExecuteMethodsInterceptor.java
+++ b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/StatementExecuteMethodsInterceptor.java
@@ -41,6 +41,13 @@ public class StatementExecuteMethodsInterceptor implements InstanceMethodsAround
         MethodInterceptResult result) throws Throwable {
         StatementEnhanceInfos cacheObject = (StatementEnhanceInfos)objInst.getSkyWalkingDynamicField();
         ConnectionInfo connectInfo = cacheObject.getConnectionInfo();
+        /**
+         * To protected the code occur NullPointException. because mysql execute system sql when constructor method in
+         * {@link com.mysql.jdbc.ConnectionImpl} class executed. but the interceptor set the connection Info after
+         * the constructor method executed.
+         *
+         * @see org.skywalking.apm.plugin.jdbc.JDBCDriverInterceptor#afterMethod(EnhancedInstance, Method, Object[], Class[], Object)
+         */
         if (connectInfo != null) {
 
             AbstractSpan span = ContextManager.createExitSpan(buildOperationName(connectInfo, method.getName(), cacheObject.getStatementName()), connectInfo.getDatabasePeer());
diff --git a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/CallableInstrumentation.java b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/CallableInstrumentation.java
similarity index 91%
rename from apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/CallableInstrumentation.java
rename to apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/CallableInstrumentation.java
index f0e2fbb6d..4d3152241 100644
--- a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/CallableInstrumentation.java
+++ b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/CallableInstrumentation.java
@@ -26,12 +26,14 @@ import org.skywalking.apm.agent.core.plugin.interceptor.enhance.ClassInstanceMet
 import org.skywalking.apm.agent.core.plugin.match.ClassMatch;
 
 import static net.bytebuddy.matcher.ElementMatchers.named;
-import static org.skywalking.apm.plugin.jdbc.mysql.define.MultiClassNameMatch.byMultiClassMath;
+import static org.skywalking.apm.plugin.jdbc.mysql.define.MultiClassNameMatch.byMultiClassMatch;
 
 /**
  * {@link CallableInstrumentation} define that the mysql-2.x plugin intercepts the following methods in the {@link
- * com.mysql.jdbc.CallableStatement} by {@link org.skywalking.apm.plugin.jdbc.mysql.CallableStatementInterceptor}. 1.
- * execute <br/> 2. executeQuery <br/> 3. executeUpdate <br/>
+ * com.mysql.jdbc.CallableStatement} by {@link org.skywalking.apm.plugin.jdbc.mysql.CallableStatementInterceptor}:
+ * 1. execute <br/>
+ * 2. executeQuery <br/>
+ * 3. executeUpdate <br/>
  *
  * @author zhangxin
  */
@@ -64,6 +66,6 @@ public class CallableInstrumentation extends ClassInstanceMethodsEnhancePluginDe
     }
 
     @Override protected ClassMatch enhanceClass() {
-        return byMultiClassMath(ENHANCE_CLASS, "com.mysql.jdbc.cj.CallableStatement");
+        return byMultiClassMatch(ENHANCE_CLASS, "com.mysql.jdbc.cj.CallableStatement");
     }
 }
diff --git a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/ConnectionInstrumentation.java b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/ConnectionInstrumentation.java
similarity index 97%
rename from apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/ConnectionInstrumentation.java
rename to apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/ConnectionInstrumentation.java
index a45048cd1..3ddded5bb 100644
--- a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/ConnectionInstrumentation.java
+++ b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/ConnectionInstrumentation.java
@@ -35,7 +35,7 @@ import static org.skywalking.apm.plugin.jdbc.define.Constants.PREPARE_STATEMENT_
 import static org.skywalking.apm.plugin.jdbc.define.Constants.RELEASE_SAVE_POINT_METHOD_NAME;
 import static org.skywalking.apm.plugin.jdbc.define.Constants.ROLLBACK_METHOD_NAME;
 import static org.skywalking.apm.plugin.jdbc.define.Constants.SERVICE_METHOD_INTERCEPT_CLASS;
-import static org.skywalking.apm.plugin.jdbc.mysql.define.MultiClassNameMatch.byMultiClassMath;
+import static org.skywalking.apm.plugin.jdbc.mysql.define.MultiClassNameMatch.byMultiClassMatch;
 
 /**
  * {@link ConnectionInstrumentation} intercepts the following methods that the class which extend {@link
@@ -115,6 +115,6 @@ public class ConnectionInstrumentation extends ClassInstanceMethodsEnhancePlugin
     }
 
     @Override protected ClassMatch enhanceClass() {
-        return byMultiClassMath(ENHANCE_CLASS, "com.mysql.cj.jdbc.ConnectionImpl");
+        return byMultiClassMatch(ENHANCE_CLASS, "com.mysql.cj.jdbc.ConnectionImpl");
     }
 }
diff --git a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/DriverInstrumentation.java b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/DriverInstrumentation.java
similarity index 91%
rename from apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/DriverInstrumentation.java
rename to apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/DriverInstrumentation.java
index 25d6ce62f..d8d1a659c 100644
--- a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/DriverInstrumentation.java
+++ b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/DriverInstrumentation.java
@@ -21,7 +21,7 @@ package org.skywalking.apm.plugin.jdbc.mysql.define;
 import org.skywalking.apm.agent.core.plugin.match.ClassMatch;
 import org.skywalking.apm.plugin.jdbc.define.AbstractDriverInstrumentation;
 
-import static org.skywalking.apm.plugin.jdbc.mysql.define.MultiClassNameMatch.byMultiClassMath;
+import static org.skywalking.apm.plugin.jdbc.mysql.define.MultiClassNameMatch.byMultiClassMatch;
 
 /**
  * {@link DriverInstrumentation} presents that skywalking intercepts {@link com.mysql.jdbc.Driver}.
@@ -31,6 +31,6 @@ import static org.skywalking.apm.plugin.jdbc.mysql.define.MultiClassNameMatch.by
 public class DriverInstrumentation extends AbstractDriverInstrumentation {
     @Override
     protected ClassMatch enhanceClass() {
-        return byMultiClassMath("com.mysql.jdbc.Driver", "com.mysql.cj.jdbc.Driver");
+        return byMultiClassMatch("com.mysql.jdbc.Driver", "com.mysql.cj.jdbc.Driver");
     }
 }
diff --git a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/MultiClassNameMatch.java b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/MultiClassNameMatch.java
similarity index 94%
rename from apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/MultiClassNameMatch.java
rename to apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/MultiClassNameMatch.java
index 839b37875..0dbb7eb4a 100644
--- a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/MultiClassNameMatch.java
+++ b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/MultiClassNameMatch.java
@@ -28,7 +28,7 @@ import org.skywalking.apm.agent.core.plugin.match.IndirectMatch;
 import static net.bytebuddy.matcher.ElementMatchers.named;
 
 /**
- * Match multiple classes name with an explicit class name.
+ * Match class with a given set of classes.
  *
  * @author zhangxin
  */
@@ -61,7 +61,7 @@ public class MultiClassNameMatch implements IndirectMatch {
         return matchClassNames.contains(typeDescription.getTypeName());
     }
 
-    public static ClassMatch byMultiClassMath(String... classNames) {
+    public static ClassMatch byMultiClassMatch(String... classNames) {
         return new MultiClassNameMatch(classNames);
     }
 }
diff --git a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/AbstractPreparedStatementInstrumentation.java b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/PreparedStatementInstrumentation.java
similarity index 70%
rename from apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/AbstractPreparedStatementInstrumentation.java
rename to apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/PreparedStatementInstrumentation.java
index bf73036f9..ba83c888e 100644
--- a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/AbstractPreparedStatementInstrumentation.java
+++ b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/PreparedStatementInstrumentation.java
@@ -23,12 +23,15 @@ import net.bytebuddy.matcher.ElementMatcher;
 import org.skywalking.apm.agent.core.plugin.interceptor.ConstructorInterceptPoint;
 import org.skywalking.apm.agent.core.plugin.interceptor.InstanceMethodsInterceptPoint;
 import org.skywalking.apm.agent.core.plugin.interceptor.enhance.ClassInstanceMethodsEnhancePluginDefine;
+import org.skywalking.apm.agent.core.plugin.match.ClassMatch;
 
 import static net.bytebuddy.matcher.ElementMatchers.named;
+import static org.skywalking.apm.plugin.jdbc.mysql.define.MultiClassNameMatch.byMultiClassMatch;
 
 /**
- * {@link AbstractPreparedStatementInstrumentation} define that the mysql-2.x plugin intercepts the following methods in
- * the {@link com.mysql.jdbc.JDBC42PreparedStatement} and {@link com.mysql.jdbc.PreparedStatement} class.
+ * {@link PreparedStatementInstrumentation} define that the mysql-2.x plugin intercepts the following methods in the
+ * {@link com.mysql.jdbc.JDBC42PreparedStatement}, {@link com.mysql.jdbc.PreparedStatement} and {@link
+ * com.mysql.cj.jdbc.PreparedStatement} class:
  * 1. execute <br/>
  * 2. executeQuery <br/>
  * 3. executeUpdate <br/>
@@ -37,9 +40,12 @@ import static net.bytebuddy.matcher.ElementMatchers.named;
  *
  * @author zhangxin
  */
-public abstract class AbstractPreparedStatementInstrumentation extends ClassInstanceMethodsEnhancePluginDefine {
+public class PreparedStatementInstrumentation extends ClassInstanceMethodsEnhancePluginDefine {
 
+    private static final String PREPARED_STATEMENT_CLASS_NAME = "com.mysql.jdbc.PreparedStatement";
     private static final String SERVICE_METHOD_INTERCEPTOR = "org.skywalking.apm.plugin.jdbc.mysql.StatementExecuteMethodsInterceptor";
+    public static final String MYSQL6_PREPARED_STATEMENT_CLASS_NAME = "com.mysql.cj.jdbc.PreparedStatement";
+    public static final String JDBC42_PREPARED_STATEMENT_CLASS_NAME = "com.mysql.jdbc.JDBC42PreparedStatement";
 
     @Override protected final ConstructorInterceptPoint[] getConstructorsInterceptPoints() {
         return new ConstructorInterceptPoint[0];
@@ -66,4 +72,8 @@ public abstract class AbstractPreparedStatementInstrumentation extends ClassInst
             }
         };
     }
+
+    @Override protected ClassMatch enhanceClass() {
+        return byMultiClassMatch(PREPARED_STATEMENT_CLASS_NAME, MYSQL6_PREPARED_STATEMENT_CLASS_NAME, JDBC42_PREPARED_STATEMENT_CLASS_NAME);
+    }
 }
diff --git a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/StatementEnhanceInfos.java b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/StatementEnhanceInfos.java
similarity index 100%
rename from apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/StatementEnhanceInfos.java
rename to apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/StatementEnhanceInfos.java
diff --git a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/StatementInstrumentation.java b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/StatementInstrumentation.java
similarity index 86%
rename from apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/StatementInstrumentation.java
rename to apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/StatementInstrumentation.java
index 0a63878ad..bd87bbc14 100644
--- a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/StatementInstrumentation.java
+++ b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/skywalking/apm/plugin/jdbc/mysql/define/StatementInstrumentation.java
@@ -26,11 +26,11 @@ import org.skywalking.apm.agent.core.plugin.interceptor.enhance.ClassInstanceMet
 import org.skywalking.apm.agent.core.plugin.match.ClassMatch;
 
 import static net.bytebuddy.matcher.ElementMatchers.named;
-import static org.skywalking.apm.plugin.jdbc.mysql.define.MultiClassNameMatch.byMultiClassMath;
+import static org.skywalking.apm.plugin.jdbc.mysql.define.MultiClassNameMatch.byMultiClassMatch;
 
 /**
- * {@link JDBC42PreparedStatementInstrumentation} intercepts the following methods in the {@link
- * com.mysql.jdbc.JDBC42PreparedStatement} class.
+ * {@link StatementInstrumentation} intercepts the following methods in the {@link
+ * com.mysql.jdbc.StatementImpl} and {@link com.mysql.cj.jdbc.StatementImpl}class.
  * 1. execute <br/>
  * 2. executeQuery <br/>
  * 3. executeUpdate <br/>
@@ -44,8 +44,9 @@ import static org.skywalking.apm.plugin.jdbc.mysql.define.MultiClassNameMatch.by
  * @author zhangxin
  */
 public class StatementInstrumentation extends ClassInstanceMethodsEnhancePluginDefine {
-    private static final String ENHANCE_CLASS = "com.mysql.jdbc.StatementImpl";
+    private static final String STATEMENT_CLASS_NAME = "com.mysql.jdbc.StatementImpl";
     private static final String SERVICE_METHOD_INTERCEPTOR = "org.skywalking.apm.plugin.jdbc.mysql.StatementExecuteMethodsInterceptor";
+    public static final String MYSQL6_STATEMENT_CLASS_NAME = "com.mysql.cj.jdbc.StatementImpl";
 
     @Override protected ConstructorInterceptPoint[] getConstructorsInterceptPoints() {
         return new ConstructorInterceptPoint[0];
@@ -78,6 +79,6 @@ public class StatementInstrumentation extends ClassInstanceMethodsEnhancePluginD
     }
 
     @Override protected ClassMatch enhanceClass() {
-        return byMultiClassMath(ENHANCE_CLASS, "com.mysql.cj.jdbc.StatementImpl");
+        return byMultiClassMatch(STATEMENT_CLASS_NAME, MYSQL6_STATEMENT_CLASS_NAME);
     }
 }
diff --git a/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/resources/skywalking-plugin.def b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/resources/skywalking-plugin.def
new file mode 100644
index 000000000..f4f6b4c6e
--- /dev/null
+++ b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/resources/skywalking-plugin.def
@@ -0,0 +1,5 @@
+mysql-5.x=org.skywalking.apm.plugin.jdbc.mysql.define.DriverInstrumentation
+mysql-5.x=org.skywalking.apm.plugin.jdbc.mysql.define.ConnectionInstrumentation
+mysql-5.x=org.skywalking.apm.plugin.jdbc.mysql.define.CallableInstrumentation
+mysql-5.x=org.skywalking.apm.plugin.jdbc.mysql.define.PreparedStatementInstrumentation
+mysql-5.x=org.skywalking.apm.plugin.jdbc.mysql.define.StatementInstrumentation
diff --git a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/test/java/org/skywalking/apm/plugin/jdbc/mysql/CreateCallableStatementInterceptorTest.java b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/test/java/org/skywalking/apm/plugin/jdbc/mysql/CreateCallableStatementInterceptorTest.java
similarity index 100%
rename from apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/test/java/org/skywalking/apm/plugin/jdbc/mysql/CreateCallableStatementInterceptorTest.java
rename to apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/test/java/org/skywalking/apm/plugin/jdbc/mysql/CreateCallableStatementInterceptorTest.java
diff --git a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/test/java/org/skywalking/apm/plugin/jdbc/mysql/CreatePreparedStatementInterceptorTest.java b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/test/java/org/skywalking/apm/plugin/jdbc/mysql/CreatePreparedStatementInterceptorTest.java
similarity index 100%
rename from apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/test/java/org/skywalking/apm/plugin/jdbc/mysql/CreatePreparedStatementInterceptorTest.java
rename to apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/test/java/org/skywalking/apm/plugin/jdbc/mysql/CreatePreparedStatementInterceptorTest.java
diff --git a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/test/java/org/skywalking/apm/plugin/jdbc/mysql/CreateStatementInterceptorTest.java b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/test/java/org/skywalking/apm/plugin/jdbc/mysql/CreateStatementInterceptorTest.java
similarity index 100%
rename from apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/test/java/org/skywalking/apm/plugin/jdbc/mysql/CreateStatementInterceptorTest.java
rename to apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/test/java/org/skywalking/apm/plugin/jdbc/mysql/CreateStatementInterceptorTest.java
diff --git a/apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/test/java/org/skywalking/apm/plugin/jdbc/mysql/StatementExecuteMethodsInterceptorTest.java b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/test/java/org/skywalking/apm/plugin/jdbc/mysql/StatementExecuteMethodsInterceptorTest.java
similarity index 100%
rename from apm-sniffer/apm-sdk-plugin/mysql-2.x-plugin/src/test/java/org/skywalking/apm/plugin/jdbc/mysql/StatementExecuteMethodsInterceptorTest.java
rename to apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/test/java/org/skywalking/apm/plugin/jdbc/mysql/StatementExecuteMethodsInterceptorTest.java
diff --git a/apm-sniffer/apm-sdk-plugin/pom.xml b/apm-sniffer/apm-sdk-plugin/pom.xml
index 187cddb8f..bae33b837 100644
--- a/apm-sniffer/apm-sdk-plugin/pom.xml
+++ b/apm-sniffer/apm-sdk-plugin/pom.xml
@@ -48,7 +48,7 @@
         <module>sharding-jdbc-1.5.x-plugin</module>
         <module>xmemcached-2.x-plugin</module>
         <module>grpc-1.x-plugin</module>
-        <module>mysql-2.x-plugin</module>
+        <module>mysql-5.x-plugin</module>
         <module>h2-1.x-plugin</module>
         <module>postgresql-8.x-plugin</module>
         <module>oracle-10.x-plugin</module>