diff --git a/CHANGES.md b/CHANGES.md
index 6f857f08a..e03ccab09 100644
--- a/CHANGES.md
+++ b/CHANGES.md
@@ -13,6 +13,7 @@ Release Notes.
 * Fix jdk-http and okhttp-3.x plugin did not overwrite the old trace header.
 * Support collecting logs of log4j, log4j2, and logback in the tracing context with a new `logger-plugin`.
 * Fix the unexpected RunningContext recreation in the Tomcat plugin.
+* Fix the potential NPE when trace_sql_parameters is enabled.
 
 #### OAP-Backend
 * Make meter receiver support MAL.
diff --git a/apm-sniffer/apm-sdk-plugin/jdbc-commons/src/main/java/org/apache/skywalking/apm/plugin/jdbc/JDBCPreparedStatementIgnorableSetterInterceptor.java b/apm-sniffer/apm-sdk-plugin/jdbc-commons/src/main/java/org/apache/skywalking/apm/plugin/jdbc/JDBCPreparedStatementIgnorableSetterInterceptor.java
index ed20408df..31f0533de 100644
--- a/apm-sniffer/apm-sdk-plugin/jdbc-commons/src/main/java/org/apache/skywalking/apm/plugin/jdbc/JDBCPreparedStatementIgnorableSetterInterceptor.java
+++ b/apm-sniffer/apm-sdk-plugin/jdbc-commons/src/main/java/org/apache/skywalking/apm/plugin/jdbc/JDBCPreparedStatementIgnorableSetterInterceptor.java
@@ -31,8 +31,10 @@ public class JDBCPreparedStatementIgnorableSetterInterceptor implements Instance
     public final void beforeMethod(EnhancedInstance objInst, Method method, Object[] allArguments,
         Class<?>[] argumentsTypes, MethodInterceptResult result) throws Throwable {
         final StatementEnhanceInfos statementEnhanceInfos = (StatementEnhanceInfos) objInst.getSkyWalkingDynamicField();
-        final int index = (Integer) allArguments[0];
-        statementEnhanceInfos.setParameter(index, Constants.SQL_PARAMETER_PLACEHOLDER);
+        if (statementEnhanceInfos != null) {
+          final int index = (Integer) allArguments[0];
+          statementEnhanceInfos.setParameter(index, Constants.SQL_PARAMETER_PLACEHOLDER);
+        }
     }
 
     @Override
diff --git a/apm-sniffer/apm-sdk-plugin/jdbc-commons/src/main/java/org/apache/skywalking/apm/plugin/jdbc/JDBCPreparedStatementNullSetterInterceptor.java b/apm-sniffer/apm-sdk-plugin/jdbc-commons/src/main/java/org/apache/skywalking/apm/plugin/jdbc/JDBCPreparedStatementNullSetterInterceptor.java
index 2d90e6644..e1935b0a7 100644
--- a/apm-sniffer/apm-sdk-plugin/jdbc-commons/src/main/java/org/apache/skywalking/apm/plugin/jdbc/JDBCPreparedStatementNullSetterInterceptor.java
+++ b/apm-sniffer/apm-sdk-plugin/jdbc-commons/src/main/java/org/apache/skywalking/apm/plugin/jdbc/JDBCPreparedStatementNullSetterInterceptor.java
@@ -30,8 +30,10 @@ public class JDBCPreparedStatementNullSetterInterceptor implements InstanceMetho
     public final void beforeMethod(EnhancedInstance objInst, Method method, Object[] allArguments,
         Class<?>[] argumentsTypes, MethodInterceptResult result) throws Throwable {
         final StatementEnhanceInfos statementEnhanceInfos = (StatementEnhanceInfos) objInst.getSkyWalkingDynamicField();
-        final int index = (Integer) allArguments[0];
-        statementEnhanceInfos.setParameter(index, "NULL");
+        if (statementEnhanceInfos != null) {
+          final int index = (Integer) allArguments[0];
+          statementEnhanceInfos.setParameter(index, "NULL");
+        }
     }
 
     @Override
diff --git a/apm-sniffer/apm-sdk-plugin/jdbc-commons/src/main/java/org/apache/skywalking/apm/plugin/jdbc/JDBCPreparedStatementSetterInterceptor.java b/apm-sniffer/apm-sdk-plugin/jdbc-commons/src/main/java/org/apache/skywalking/apm/plugin/jdbc/JDBCPreparedStatementSetterInterceptor.java
index 3ab0f6d92..a713ebcaa 100644
--- a/apm-sniffer/apm-sdk-plugin/jdbc-commons/src/main/java/org/apache/skywalking/apm/plugin/jdbc/JDBCPreparedStatementSetterInterceptor.java
+++ b/apm-sniffer/apm-sdk-plugin/jdbc-commons/src/main/java/org/apache/skywalking/apm/plugin/jdbc/JDBCPreparedStatementSetterInterceptor.java
@@ -30,9 +30,11 @@ public class JDBCPreparedStatementSetterInterceptor implements InstanceMethodsAr
     public final void beforeMethod(EnhancedInstance objInst, Method method, Object[] allArguments,
         Class<?>[] argumentsTypes, MethodInterceptResult result) throws Throwable {
         final StatementEnhanceInfos statementEnhanceInfos = (StatementEnhanceInfos) objInst.getSkyWalkingDynamicField();
-        final int index = (Integer) allArguments[0];
-        final Object parameter = allArguments[1];
-        statementEnhanceInfos.setParameter(index, parameter);
+        if (statementEnhanceInfos != null) {
+          final int index = (Integer) allArguments[0];
+          final Object parameter = allArguments[1];
+          statementEnhanceInfos.setParameter(index, parameter);
+        }
     }
 
     @Override